Sea Moss for Pemphigus Vulgaris: Anti-Inflammatory, Desmoglein Autoimmunity & Mucocutaneous Support

Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease affecting ~1-5 per million annually, caused by IgG autoantibodies against desmoglein-1 and desmoglein-3 (Dsg1/Dsg3), transmembrane desmosomal cadherins in stratified squamous epithelium of mucous membranes and skin. PV involves Th2/Th17 IL-4/IL-5/IL-17/IL-21 B-cell dysregulation, complement activation, and NF-kB-driven keratinocyte apoptosis (acantholysis). Sea moss fucoidan modulates NF-kB and B-cell hyperactivation; omega-3 EPA/DHA modulates Th2/Th17 eicosanoid cascades; selenium supports keratinocyte GPx antioxidant protection and wound healing; zinc supports tight junction/desmosome integrity and epithelial barrier repair. Prednisone, rituximab (CD20 anti-B-cell), and mycophenolate mofetil are standard; sea moss provides anti-inflammatory nutritional support alongside specialist care.

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