Sea Moss for Cogan Syndrome: Anti-Inflammatory, Interstitial Keratitis/Vestibuloauditory Autoimmunity & Mineral Support

Cogan syndrome is a rare autoimmune vasculitis affecting young adults (~1/million), characterized by the classic triad of non-syphilitic interstitial keratitis (IK), vestibuloauditory dysfunction (Meniere-like attacks, sensorineural hearing loss, vertigo), and large/medium vessel vasculitis (aortitis in 10-15%, subclavian/mesenteric arteritis) with aortic insufficiency risk; driven by IgG autoantibodies against inner ear antigens (anti-cochlin/COCH, anti-Hsp70/KHSRP, anti-CD148/DPPIV), corneal cross-reactive peptide antigens, CD4+ Th1/Th17 corneal stroma infiltration, complement C3/C4 cochlear deposition, NF-kB/IL-6/TNF-alpha vascular endothelial inflammatory cascade, and ANCA positivity in atypical variant. Sea moss fucoidan modulates NF-kB/IL-6, complement C3/C4, and VCAM-1 vascular endothelial cascades; selenium supports corneal/cochlear GPx1/GPx4; omega-3 modulates vascular PGI2/TXA2 and resolvin D1; zinc supports Cx26 cochlear hair cell repair and corneal MMP-1 metalloproteases. Oral corticosteroids first-line for IK and hearing; MTX/TNF inhibitors for vasculitis; cochlear implants for irreversible SNHL.

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