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Polymyositis (PM) is an idiopathic inflammatory myopathy causing proximal muscle weakness via CD8+ T-cell endomysial invasion and anti-Jo-1/PL-7/PL-12 antisynthetase autoantibodies, often with ILD overlap. PM is driven by cytotoxic T-cell-mediated myofiber destruction, MHC-I upregulation on muscle fibers, and type I interferon signaling. Sea moss selenium supports muscle GPx antioxidant protection; fucoidan modulates CD8+ T-cell NF-kB signaling and TGF-beta ILD fibrosis; zinc supports satellite cell myogenesis and muscle repair; omega-3 precursors modulate LTB4/PGE2 pro-inflammatory eicosanoids. Corticosteroids and immunosuppressants (methotrexate, azathioprine, IVIG) are standard; sea moss provides muscle and anti-inflammatory nutritional support alongside rheumatologist care.
