Granulomatosis with polyangiitis (GPA, formerly Wegener's) is an ANCA-associated small-to-medium vessel vasculitis affecting 50,000+ Americans, driven by PR3-ANCA/MPO-ANCA neutrophil activation causing necrotizing granulomatous inflammation of the upper/lower respiratory tract and glomerulonephritis. GPA involves NF-kB, NET formation, and complement activation. Sea moss fucoidan modulates NF-kB and complement; selenium supports neutrophil GPx and renal antioxidant protection; zinc supports Treg immune regulation; omega-3 modulates eicosanoid inflammatory amplification. Rituximab, cyclophosphamide, and methotrexate are standard; sea moss provides anti-inflammatory nutritional support alongside rheumatologist and nephrologist care.

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