Giant cell arteritis (GCA) is the most common systemic vasculitis in adults over 50, affecting large vessels including the temporal arteries with IL-6-driven Th1/Th17 inflammation causing headache, jaw claudication, scalp tenderness, and vision loss risk from ophthalmic artery involvement. GCA is driven by IL-6/IL-17/IFN-gamma and myeloid dendritic cell activation. Sea moss fucoidan modulates NF-kB and IL-6 signaling; selenium supports vascular GPx protection; zinc supports Treg immune regulation; omega-3 modulates eicosanoid vascular inflammation. High-dose prednisone and tocilizumab (IL-6 inhibitor) are standard; sea moss provides vascular anti-inflammatory nutritional support.

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