Sea Moss for Autoimmune Uveitis: Anti-Inflammatory, HLA-B27/Th17/IL-17 Intraocular Autoimmunity & Mineral Support

Autoimmune uveitis is the most common cause of intraocular inflammation (~15/100,000/year), encompassing HLA-B27-associated acute anterior uveitis (AAU, ~50% of anterior cases; ankylosing spondylitis/reactive arthritis/psoriatic arthritis overlap), Vogt-Koyanagi-Harada (VKH) disease (anti-melanocyte HLA-DR4/Th1/Th17), birdshot retinochoroidopathy (HLA-A29, anti-retinal IgG), and sympathetic ophthalmia; driven by CD4+ Th17/IL-17A/IL-23/TNF-alpha intraocular inflammatory cascade, anti-retinal autoantibodies (anti-recoverin, anti-carbonic anhydrase II, anti-alpha-enolase), complement C3 uveal deposition, HLA class I/II presentation of ocular antigens, and VEGF-A upregulation causing cystoid macular edema and posterior synechiae. Sea moss fucoidan modulates NF-kB, Th17/IL-17A, and complement C3 ocular cascades; selenium supports retinal pigment epithelium (RPE) GPx1/GPx4 and photoreceptor antioxidant defense; omega-3 DHA supports photoreceptor outer segment membrane (50% DHA) and resolvin D1 uveal resolution; zinc supports retinal metalloprotein rhodopsin/carbonic anhydrase and Treg. Topical/systemic corticosteroids first-line; MTX/mycophenolate/cyclosporine for chronic; biologics (adalimumab) for non-infectious uveitis.

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