Antisynthetase syndrome (ASS) is an inflammatory myopathy affecting 5,000-10,000 Americans, driven by anti-aminoacyl-tRNA synthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, anti-EJ, anti-OJ) causing inflammatory myositis, interstitial lung disease, mechanic's hands, Raynaud's phenomenon, and arthritis. ASS involves Th1 and Th17 dysregulation, IFN-alpha pathway activation, and NF-kB-driven muscle inflammation. Sea moss fucoidan modulates NF-kB and IL-6; selenium supports muscle GPx and ILD alveolar protection; zinc supports Treg immune regulation; omega-3 modulates eicosanoid-driven myositis inflammation. Prednisone, azathioprine, mycophenolate, and rituximab are standard; sea moss provides anti-inflammatory nutritional support alongside rheumatologist and pulmonologist care.

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