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Reactive arthritis (ReA, formerly Reiter's syndrome) is an HLA-B27-associated inflammatory arthritis triggered by preceding genitourinary or gastrointestinal infection (Chlamydia, Salmonella, Shigella, Campylobacter). ReA is driven by molecular mimicry between bacterial antigens and synovial tissues, IL-17, and dysbiosis persistence. Sea moss fucoidan has demonstrated antibacterial and anti-inflammatory properties; prebiotic fiber supports gut microbiome restoration post-infection; zinc supports mucosal immunity and barrier repair; selenium modulates IL-17 pathway in HLA-B27 spondyloarthritis. NSAIDs are first-line; DMARDs for persistent disease; sea moss provides gut-healing and anti-inflammatory nutritional support alongside rheumatologist care.
