Sea Moss for Orbital Inflammatory Disease: Anti-Inflammatory, IgG4/T-Cell Orbital Pseudotumor & Mineral Support

Idiopathic orbital inflammatory disease (IOID, orbital pseudotumor) is a nonspecific orbital inflammatory syndrome (~1-2/million) with a significant IgG4-related subset (~25-35%); driven by CD4+ T-cell/IgG4 plasma cell/macrophage infiltration of lacrimal gland (dacryoadenitis), extraocular muscles (myositis), orbital fat (diffuse), Tenon's capsule (posterior scleritis/perineuritis), NF-kB/IL-6/IL-4/TGF-beta1/SMAD orbital fibrosis cascade, complement C3/C4 deposition, and VCAM-1/ICAM-1 endothelial activation causing painful proptosis, diplopia, periorbital edema, and vision loss from optic nerve compression or corneal exposure. Sea moss fucoidan modulates NF-kB, TGF-beta1/SMAD orbital fibrosis, complement C3/C4, and VCAM-1; selenium supports orbital fibroblast GPx1/GPx4 antioxidant defense; omega-3 modulates orbital eicosanoid balance and resolvin D1/E1 anti-fibrotic resolution; zinc supports orbital MMP-1/13 collagenase metalloenzymes and Treg. Oral corticosteroids are first-line (70-90% response); radiation for steroid-resistant; rituximab for IgG4 variant; orbital decompression for vision-threatening compression.

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