Behcet's disease (BD) is a systemic vasculitis causing recurrent oral ulcers, genital ulcers, uveitis, and vascular/neurological complications. BD is driven by HLA-B51-associated neutrophil hyperactivation, IL-17/IL-23 axis dysregulation, endothelial damage, and Th1 inflammation. Sea moss fucoidan has demonstrated anti-inflammatory properties modulating neutrophil and IL-17 signaling; selenium supports endothelial GPx antioxidant protection; zinc supports mucosal epithelial repair of oral and genital ulcers; iodine modulates thyroid-vascular interactions. Colchicine, azathioprine, and biologics (infliximab, secukinumab) are standard; sea moss provides mucosal healing nutritional support alongside specialist care.

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